ZO Acne Complex (50ml)

Product image of ZO® Acne Complex in sleek silver and white packaging, formulated to target all stages of acne formation, reduce active breakouts, prevent future blemishes, and improve the appearance of post-acne marks and texture

Product image of ZO® Acne Complex placed on top of a white box, with a visible swatch of the lightweight treatment beside it, highlighting its smooth texture and advanced formula designed to treat breakouts, prevent future acne, and improve post-acne marks and skin texture

Before and after image of a woman using ZO® Acne Complex, showing visible improvement from baseline to week 12, with reduced acne breakouts, smoother skin texture, and a clearer, more balanced complexion

Step-by-step image of the ZO® Acne Protocol regimen, highlighting ZO® Acne Control as a key product in the routine, designed to target and treat breakouts, reduce excess oil, and support clearer, healthier skin

ZO Acne Complex (50ml)

by ZO

$195.00

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ZO Acne Complex (50ml)

Take control of breakouts from every angle with ZO® Acne Complex. This all-in-one powerhouse targets the full acne cycle—treating existing pimples, preventing future ones, and visibly improving post-acne marks and texture. Lightweight, effective, and clinically proven, it’s your go-to for clearer, smoother, more confident skin.

Appropriate for All Skin Types. Best for Oily + Blemish-Prone Skin.

Available in:

50 mL / 1.7 Fl. Oz.

TSA Approved | Fragrance-free

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Product Description

Multi-Action Blemish Treatment | Clinically Proven Acne & Scar Solution

Experience a revolutionary 360° blemish treatment designed to target every stage of breakouts—from formation to healing. This advanced, fragrance-free formula is clinically proven to:

✔ Reduce blemish severity and help prevent future breakouts
✔ Minimize post-blemish marks and improve textural scarring
✔ Support clear, healthy-looking skin with powerful active ingredients

Ideal for acne-prone, oily, and combination skin, this fast-absorbing treatment works to visibly refine pores, calm redness, and promote a more even complexion. Get clearer skin with a dermatologist-approved solution that fights acne at its source.

Acne Complex Benefits:

Clears all grades of acne and helps to prevent future blemishes
Minimizes the appearance of post-acne red + brown marks
Improves the look of textural acne scarring and visibly smoother skin
Creamy treatment serum absorbs quickly

What's Inside

Key Ingredients:

1% Retinol in a Micro-emulsion: Promotes healthy exfoliation in pores to prevent future acne and improves the look of textural scarring
2% Encapsulated Salicylic Acid: Unclogs impactions to clear existing breakouts in a delivery system that provides extended pore-clearing action
Potassium Azeloyl Diglycinate + Cetyl Tranexamate Mesylate: Azelaic acid and tranexamic acid derivatives; minimize the formation of post-acne red + brown marks for clear, even skin tone
ZO-RRS²®: Exclusive plant stem cell complex soothes visible redness while helping to neutralize aging free radicals

All Ingredients:

Water (Aqua/Eau), Glycerin, Dimethicone, Niacinamide, Pentylene Glycol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Propanediol, Tromethamine, Acetyl Glucosamine, Salicylic Acid, Gluconolactone, Papain, Bentonite, Piroctone Olamine, Phytic Acid, Dipotassium Glycyrrhizate, Caprylyl Glycol, Panthenol, Allantoin, Xanthan Gum, Hydroxyacetophenone, Trehalose, Sodium Bisulfite, Ergothioneine, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin, Chlorphenesin

Please note: Ingredients are subject to change as ZO® Skin Health regularly updates formulations to comply with evolving skincare science and regulatory standards. Always refer to your product packaging for the most accurate, up-to-date ingredient list.

How to Use

Due to the unique potency of Acne Complex, begin use gradually.

After Getting Skin Ready®, apply a thin layer 2-3 times/week.
Gradually increase to daily use as tolerated.
Pair with ZO Hydrating Crème to soothe + comfort skin.
Wear broad-spectrum sunscreen SPF 30 or higher daily during initial retinol acclimation.
Provider monitoring is recommended.