Upgraded with 20% more Proxylane than the original formula and enriched with a boosted Wild Fruit Flavonoid blend, the SkinCeuticals A.G.E. Interrupter Advanced also introduces 0.1% Glycyrrhetinic Acid to soothe and brighten. Clinically proven to improve firmness, elasticity, radiance, and five key wrinkle zones—including forehead lines, crow’s feet, and marionette lines—it’s the ultimate daily cream for visibly stronger, smoother, and more luminous skin.

One main cause of internal aging is glycation, which occurs when excess glucose molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.) that lead to severe skin wrinkling.

Key Benefits 

• Reduces the appearance of 5 types of wrinkles
• Reduces the appearance of global fine lines by -14.1% and targeted deep wrinkles by -7.9%
• Enhances skin's firmness, elasticity, overall radiance, and improves tone for a healthier-looking complexion
• Delivers rich hydration, with a luxurious, satin finish

Key Ingredients

18% Concentrated Proxylane™ - Designed to help support skin’s own G.A.G. synthesis and restore water and nutrients to the skin, 20% more active than the 30% Proxylane in the old version.

4.25% Wild Fruit Flavonoids - With blueberry and pomegranate extracts specifically targets UV-induced glycation.

0.1% Glycyrrhetinic Acid - Anti-inflammatory agent to sooth skin.

3% Hepes - activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation

1% Niacinamide - strengthens the skin’s moisture barrier and reduces the appearance of discoloration and blotchiness.

Ingredients

AQUA / WATER ● HYDROXYPROPYL TETRAHYDROPYRANTRIOL ● GLYCERIN ● PROPYLENE GLYCOL ● STEARIC ACID ● BUTYROSPERMUM PARKII BUTTER / SHEA BUTTER ● HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID ● PALMITIC ACID ● PENTYLENE GLYCOL ● OLEYL ALCOHOL ● ARACHIDYL ALCOHOL ● MYRISTYL MYRISTATE ● PANTHENOL ● NIACINAMIDE ● DIMETHICONE ● ISONONYL ISONONANOATE ● BIS-PEG/PPG-16/16 PEG/PPG-16/16 DIMETHICONE ● GLYCERYL STEARATE ● CANDELILLA CERA / CANDELILLA WAX ● BEHENYL ALCOHOL ● PEG-100 STEARATE ● SODIUM POLYACRYLATE ● PENTAERYTHRITYL TETRAISOSTEARATE ● 4-T-BUTYLCYCLOHEXANOL ● ARACHIDYL GLUCOSIDE ● CAPRYLYL GLYCOL ● XANTHAN GUM ● CHLORPHENESIN ● MYRISTIC ACID ● CAPRYLIC/CAPRIC TRIGLYCERIDE ● GLYCYRRHETINIC ACID ● PARFUM / FRAGRANCE ● SORBITOL ● VACCINIUM MYRTILLUS FRUIT EXTRACT ● POTASSIUM HYDROXIDE ● ADENOSINE ● CITRIC ACID ● PUNICA GRANATUM FRUIT EXTRACT ● LIMONENE ● COUMARIN ● LINALOOL ● PENTAERYTHRITYL TETRA-DI-T-BUTYL HYDROXYHYDROCINNAMATE

Directions AM/PM

Apply once or twice daily to face, neck, and chest. If using in the morning, apply after a SkinCeuticals Vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

Caution

For external use only. Avoid direct contact with the eyes.

The science behind SkinCeuticals A.G.E. Interrupter Advanced

Intrinsic aging, caused by internal factors such as hormonal shifts and metabolic slowdown, contributes to the appearance of skin sagging, creping, and cracking.

Glycation, a major factor of intrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibres and prompt the formation of Advanced Glycation End-products (A.G.E.) that may lead to the appearance of aging.

A.G.E. Interrupter Advanced is a uniquely-textured formulation optimized to help improve the visible signs of aging attributed to intrinsic aging. This potent anti-wrinkle cream features three powerful ingredients proven to improve visible signs of aging including wrinkles, loss of firmness, crepiness and thinning appearance.